23 juni 2026
73 min
What if the supplements you've been taking to feel better are actually the reason you feel worse?
That's exactly what happened to me, and it sent me down a rabbit hole that led to one of the most important conversations I've had about my own health. Today I'm sitting down with my close friend and personal doctor, Dr. Sabrina Solt, a regenerative medicine physician and peptide expert who has been in this field for over a decade.
We start with the question that started everything for me: why was I wired at 3am, crashing every afternoon, and reacting to the exact supplements I thought were helping? Dr. Solt breaks down the cortisol-prolactin connection that most doctors never test for, explains why elevated cholesterol in midlife women is often a protective response rather than a red flag, and walks us through the inflammation markers that actually tell the full story of what's happening inside the body.
Then we go deep on what she calls the upstream-downstream problem, the real reason why things like methylated B vitamins, NAD drips, and glutathione pushes can backfire so badly in certain women, and what to do instead. She explains the genetic piece around MTHFR and COMT variations, why "more" is rarely the answer, and what supporting downstream clearance actually looks like in practice.
From there, we get into peptides. Dr. Solt gives a grounded, clinical breakdown of BPC-157, TB-500, KPV, the copper peptide GHKCU, growth hormone releasing peptides, and the serious cautions around GLP microdosing gone wrong. She also shares her vision for what medicine could look like if doctors were equally fluent in peptides and pharmaceuticals.
This is the conversation I've been wanting to bring to you for a long time. Dr. Sabrina Solt is one of the most precise and brilliant minds I know, and she does not hold back.
WE GO DEEP ON:
The cortisol-prolactin connection most doctors never test
Why high cholesterol isn't always the villain (and what MPO reveals)
The upstream-downstream mistake making "healthy" habits backfire
Why NAD and glutathione drips can be dangerous for some people
A no-BS peptide breakdown: BPC-157, TB-500, KPV, copper peptides, and more
The truth about GLP microdosing and its risks
What to fix before you ever try a peptide
Catch the full episode on YOUTUBE HERE: https://bit.ly/MidlifeConversationsYouTube
Learn More About Sabrina Solt
Instagram ➜ http://www.instagram.com/drsolt
Website ➜ http://www.stemcelltherapypro.com/
Peptide Membership Website ➜ https://dr-solts-peptide-corner.circle.so/forms/dfdcc2cd
Thank you to our show sponsors:
QUANTUM UPGRADE: Try Quantum Upgrade completely free for 15 days—no credit card required. Use code NATALIEJILL at checkout on https://quantumupgrade.io/start
TIMELINE: Timeline is offering 20% off your order of Mitopure! Go to https://timeline.com/NATALIEJILL
Free Gifts for being a listener of Midlife Conversations!
Mastering the Midlife Midsection Guide: https://theflatbellyguide.com/
Age Optimizing and Supplement Guide: https://ageoptimizer.com
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Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before making any changes to your current regimen.
Information provided in this podcast and the use of any products or services related to this podcast does not create a client-patient relationship between you and the host of Midlife Conversations or you and any doctor or provider interviewed and featured on this show. Information and statements may have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.
Advertising Disclosure: Some episodes of Midlife Conversations may be sponsored by products or services discussed during the show. The host may receive compensation for such advertisements or if you purchase products through affiliate links. Opinions expressed about products or services are those of the host and/or guests and do not necessarily reflect the views of any sponsor. Sponsorship does not imply endorsement of any product or service by healthcare professionals featured on this podcast.
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Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40
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