Dr. David Perlmutter on Menopause, Metabolism & Protecting Your Brain

Women are far more likely than men to develop Alzheimer’s disease, and Dr. David Perlmutter believes one of the most important pieces of that story is metabolic health.

In this episode of Live Like a Girl, Dr. Perlmutter joins Dr. Mindy to explain what happens when the brain’s immune cells shift from protective to destructive, why menopause may increase vulnerability, and how blood sugar, insulin resistance, visceral fat, inflammation, mitochondrial health, and lifestyle all influence brain aging.

They also discuss HRT, GLP-1 medications, ketones, fasting, fiber, exercise, BNDF, sleep, and what women can begin doing in their 30s, 40s, and 50s to support long-term cognitive health.

In This Episode, You’ll Learn

• Why women face a higher risk of Alzheimer’s
• How menopause may affect brain metabolism
• Why belly fat and insulin resistance matter for brain health
• The blood markers Dr. Perlmutter watches most closely
• What emerging research says about GLP-1 drugs and the brain
• The lifestyle habits Dr. Perlmutter prioritizes for prevention

Resources Mentioned

• Brain Defenders
• Tanzi Study
• Cochrane Review

More on Dr. David Perlmutter

• https://drperlmutter.com/
• http://braindefenders.com/
• https://www.instagram.com/davidperlmutter/
• https://www.youtube.com/user/DavidPerlmutterMD
• https://x.com/davidperlmutter
• linkedin.com/in/david-perlmutter-md

For more resources related to today’s episode, visit the podcast episode page: https://www.drmindypelz.com/ep363/

Connect with Dr. Mindy:

• Join Reset Academy
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Disclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle.