S2 Episode 3: Treating Psoriatic Arthritis: The Role of Methotrexate and csDMARDs in Comparison to Biologics

Drs Stanley Cohen and Caylib Durand discuss the treatment paradigm for psoriatic arthritis and the role of methotrexate and other conventional synthetic disease-modifying antirheumatic drugs.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/970783). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Psoriatic Arthritis https://emedicine.medscape.com/article/2196539-overview

Psoriatic Arthritis: Expert Review and Commentary From Published Literature https://themedicalxchange.com/en/2021/11/23/3021-new-grappa-treatment-recommendations-for-psoriatic-arthritis/

GRAPPA Treatment Recommendations: 2021 Update https://www.jrheum.org/content/early/2022/03/10/jrheum.211331

What Is GRADE? https://bestpractice.bmj.com/info/us/toolkit/learn-ebm/what-is-grade/

Rheumatoid Arthritis (RA) Workup https://emedicine.medscape.com/article/331715-workup#c6

leflunomide (Rx) https://reference.medscape.com/drug/arava-leflunomide-343203

sulfasalazine (Rx) https://reference.medscape.com/drug/azulfidine-sulfasalazine-343280

AB0533 Combination of Methotrexate and Leflunomide Is Safe and Has Good Drug Retention Among Patients With Psoriatic Arthritis https://ard.bmj.com/content/80/Suppl_1/1298.1

apremilast (Rx) https://reference.medscape.com/drug/otezla-apremilast-999915

Etanercept and Methotrexate as Monotherapy or in Combination for Psoriatic Arthritis: Primary Results From a Randomized, Controlled Phase III Trial https://onlinelibrary.wiley.com/doi/10.1002/art.40851

Psoriatic Arthritis Treatment & Management https://emedicine.medscape.com/article/2196539-treatment

Iritis and Uveitis https://emedicine.medscape.com/article/798323-overview

Paradoxical Gastrointestinal Effects of Interleukin-17 Blockers https://ard.bmj.com/content/79/9/1132