S1 Episode 6: Challenges and Opportunities: Treatment and Prevention of Moderate to Severe Childhood Asthma

Drs Wechsler, Bacharier, and Phipatanakul discuss moderate to severe childhood asthma.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969691). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources:

Precision Interventions for Severe and/or Exacerbation-Prone Asthma (PrecISE) Network https://preciseasthma.org/preciseweb/

Inhaled Corticosteroid Therapy in Children: An Assessment of the Potential for Side Effects https://www.ncbi.nlm.nih.gov/pmc/articles/PMC475319/pdf/thorax00304-0005.pdf

Inhaled Corticosteroids in Children: Effects on Bone Mineral Density and Growth https://linkinghub.elsevier.com/retrieve/pii/S2213-2600(14)70024-4

Aerochamber https://aerochamber.com/

Pulmonary Function Testing https://emedicine.medscape.com/article/303239-overview

Using Impulse Oscillometry in Clinical Practice https://www.medscape.com/viewarticle/862265

Global Initiative for Asthma Guidelines https://ginasthma.org/

National Asthma Education Prevention Program Guidelines https://www.nhlbi.nih.gov/health-topics/asthma-management-guidelines-2020-updates

Omalizumab Prescribing Information https://www.gene.com/download/pdf/xolair_prescribing.pdf

Mepolizumab Prescribing Information https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Nucala/pdf/NUCALA-PI-PIL-IFU-COMBINED.PDF

Benralizumab Prescribing Information https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/3647bed4-ce91-4fe7-9bc5-32dbee73f80a/3647bed4-ce91-4fe7-9bc5-32dbee73f80a_viewable_rendition__v.pdf

Dupilumab in Children With Uncontrolled Moderate-to-Severe Asthma https://www.nejm.org/doi/10.1056/NEJMoa2106567

Dupilumab Prescribing Information https://www.regeneron.com/downloads/dupixent_fpi.pdf

Tezepelumab Prescribing Information https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/e306dc06-d580-4457-b15f-9f28545ad63a/e306dc06-d580-4457-b15f-9f28545ad63a_viewable_rendition__v.pdf

Preventing Asthma in High Risk Kids (PARK) With Omalizumab: Design, Rationale, Methods, Lessons Learned and Adaptation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887056/