Episode 4: GLP-1 Not Working? Weight Loss Plateau, and What Happens Next

GLP-1 not working like before? You’re not alone.

Many people using GLP-1 medications such as Ozempic, Wegovy, or Mounjaro reach a point where weight loss slows, fatigue increases, and progress feels stalled. This phase is often referred to as a weight loss plateau, but it is frequently misunderstood.

In this episode of Weight and Measure, we break down what is actually happening during this stage of the GLP-1 journey and how both patients and clinicians can better navigate it.

Zach and Mike are joined by Angela Fitch, MD and Robyn Pashby, PhD to explore the physiological, behavioral, and clinical factors behind stalled progress and what it means for long-term care.

This episode covers:
• Why GLP-1 medications can feel like they have stopped working
• What a weight loss plateau really represents
• GLP-1 related fatigue and how to approach it
• When to adjust treatment plans and expectations
• The shift from weight loss to long term metabolic health
• Why body composition matters more than the number on the scale

This phase of treatment is where many patients begin to question the process, but it is also where the focus shifts toward sustainability, health outcomes, and long-term success.

If you are navigating a plateau, supporting patients on GLP-1 therapy, or working in obesity care, this episode provides practical insight into what comes next.

GLP-1 plateau, GLP-1 not working, Ozempic plateau, Wegovy stopped working, Mounjaro weight loss stall, GLP-1 fatigue, weight loss plateau, obesity care, metabolic health, body composition, weight management, obesity medicine