#230 Progesterone for Sleep, GLP-1 Microdosing, and HRT/Peptide Insights with Dr. K

Dr. Mike Hart welcomes Ksenia Petrushkina back for a wide-ranging conversation about using hormones, GLP-1 medications, and peptides more thoughtfully. They explore why lower, individualized doses of tirzepatide may improve tolerability, which blood markers should be monitored during treatment, and how progesterone may support sleep through its effects on GABA. They also discuss women's hormone replacement therapy, personalized testosterone dosing, TRT and fertility, thyroid treatment, low-dose naltrexone, and the difference between evidence-based peptide use and exaggerated online claims.

Ksenia Petrushkina is a clinician whose work focuses on hormone optimization, peptide therapy, metabolic health, and highly individualized treatment. Through comprehensive blood testing, symptom assessment, careful dose adjustments, and ongoing patient monitoring, she helps men and women better understand how hormones, medications, and peptides may affect their energy, sleep, inflammation, fertility, body composition, and long-term health. Her approach challenges standardized protocols and social-media biohacking trends, emphasizing personalized medicine, responsible prescribing, and evaluating one intervention at a time.

 

Quick Coherence Technique — HeartMath

https://help.heartmath.com/introduction/quick-coherence-technique/

The Levels of Ghrelin, Glucagon, Visfatin and GLP-1 Are Decreased in the Peritoneal Fluid of Women with Endometriosis — Aleksey M. Krasnyi et al.

https://pubmed.ncbi.nlm.nih.gov/36142272/

Women's Health Initiative — National Heart, Lung, and Blood Institute, National Institutes of Health

https://www.nhlbi.nih.gov/science/womens-health-initiative-whi

Facial Beauty Age Support Serum for Estrogen Deficiency — Quicksilver Scientific

https://www.quicksilverscientific.com/products/facial-beauty-serum

Peptides: The Science, Uses & Safety — Dr. Andrew Huberman and Dr. Abud Bakri

https://www.hubermanlab.com/episode/peptides-the-science-uses-and-safety-abud-bakri

Vladimir Khavinson Publications — Professor Vladimir Khavinson

https://khavinson.info/publications

 

Show Notes

 

00:00 Welcome to the Hart2Heart Podcast

00:57 GLP-1 Starting Doses

03:39 GLP-1 Anti Inflammation Aging

07:15 Motility Supplements Side Effects

09:02 Tirzepatide vs Semaglutide

11:46 Adrenal Fatigue Myth

13:23 Fatigue Bloodwork Checklist

16:16 TRT Hematocrit Sleep Apnea

19:01 Underrated Blood Tests

20:06 Womens HRT Basics

22:21 Testosterone for Women

25:19 Thyroid Treatment LDN NAD

29:31 Progesterone GABA Sleep

32:25 Progesterone for Men Debate

33:43 Testosterone Injection Frequency

36:05 TRT Dosing Frequency

36:45 Why TRT Stops Working

37:50 Creams vs Injections

39:08 Fertility and HCG

41:46 Peptides vs Pharma

44:17 HGH and Secretagogues

45:12 5-Amino-1-MQ Hype

48:15 Topical GHK-Cu Skincare

50:25 Injectable Copper Peptide Hair

52:26 BPC 157 and TB500

58:25 Thymosin Alpha 1 Immunity

01:01:13 Mitochondrial Peptides

01:03:20 Endo 205 and New Peptides

01:04:17 Kavinson and Epitalon

01:08:21 Wrap Up and Where to Find

 

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary 

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as 

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

 

Connect with Dr. Mike Hart

Instagram: @drmikehart
Twitter: @drmikehart
Facebook: @drmikehart