#231 Dr. Kyle Gillett on Nootropics, Peptides, GLP-1 Side Effects, Hair Loss, and Microplastics

Dr. Kyle Gillett joins Dr. Mike Hart to discuss safer, more practical approaches to biohacking, performance, and longevity. They cover indoor microplastic exposure, bromantane, low-dose nicotine, healing peptides, BPC-157 safety, tesamorelin, growth hormone, GLP-1 digestive side effects, NAD support, carnitine, hair loss, sleep medications, and longevity treatments. Dr. Gillett separates promising interventions from overhyped protocols while emphasizing evidence, appropriate dosing, consistency, and individual risk.

Dr. Kyle Gillett is a physician and founder of Gillett Health whose work focuses on personalized hormone care, metabolic health, performance, and longevity. He uses laboratory results, symptoms, medical history, lifestyle, and treatment response to guide decisions about hormones, medications, peptides, and supplements. He also hosts the Gillett Health Podcast and founded Sage Bio.

 

[Gillett Health] — Dr. Kyle Gillett and James O'Hara
https://gilletthealth.com/

[The Gillett Health Podcast] — Dr. Kyle Gillett and James O'Hara
https://podcasts.apple.com/us/podcast/the-gillett-health-podcast/id1631735999

[Sage Bio Laboratory Testing] — Sage Bio, Inc.
https://www.sagebio.com/

[AirDoctor Air Purifiers] — AirDoctor and Ideal Living
https://airdoctorpro.com/

[Consensus Research Search] — Consensus
https://consensus.app/

[Google Scholar] — Google
https://scholar.google.com/

[Cravv Cytisine Product Information] — Health Canada
https://health-products.canada.ca/lnhpd-bdpsnh/info?licence=80072525

[Juven Therapeutic Nutrition] — Abbott Nutrition
https://www.abbottnutrition.com/our-products/juven

[EGRIFTA WR Tesamorelin Prescribing Information] — U.S. Food and Drug Administration
https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/022505s020lbl.pdf

[QUVIVIQ Daridorexant Information] — Idorsia Pharmaceuticals
https://www.quviviq.com/

[DAYVIGO Lemborexant Information] — Eisai
https://www.dayvigo.com/

[Micro- and Nanoplastics in Coronary Circulation Study] — Pasquale Paolisso and colleagues, European Heart Journal
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag447/8725569

[CJC-1295 FDA Review Materials] — U.S. Food and Drug Administration, Pharmacy Compounding Advisory Committee
https://www.fda.gov/advisory-committees/advisory-committee-calendar/updated-meeting-time-and-public-participation-information-december-4-2024-meeting-pharmacy

[Kyle Gillett, MD on Instagram] — Dr. Kyle Gillett
https://www.instagram.com/kylegillettmd/

 

Show Notes

00:00 Welcome to the Hart2Heart Podcast

00:45 Bromantane Overview

02:16 How Bromantane Works

04:45 Trump Debate Stack

06:03 Nicotine Microdosing

08:39 Cartilax vs BPC

12:06 Ultimate Healing Stack

14:09 Healing Supplements

16:26 Tesamorelin Benefits

21:09 Growth Hormone Dosing

22:54 Kids and Height

25:13 Selank and Benzo Taper

28:59 Best Time for BPC

31:03 BPC Safety Risks

33:00 GLP1 Motility Fixes

34:39 Low Dose Naltrexone Uses

36:06 LDN and Alcohol Effects

37:10 GLP-1 Heartburn Fixes

38:42 GLP-1s and Drinking

40:18 Hangover Supplement Stack

42:55 Oral vs Injectable Carnitine

45:27 NAD+ Shots vs Precursors

47:35 Hair Loss Stack for Men

50:44 Topical Dutasteride Strategy

56:06 Hair Loss Stack for Women

56:59 Top Longevity Meds

01:00:28 Aspirin Nuance and Lp

01:02:25 TUDCA for Gallbladder

01:04:36 Leptin Resistance Basics

01:06:33 Microplastics and Indoor Air

01:10:03 Wrap Up and Where to Find

 

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary 

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as 

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

 

Connect with Dr. Mike Hart

Instagram: @drmikehart
Twitter: @drmikehart
Facebook: @drmikehart