Drug Development in Obesity

Guests: Pete Bak and Christian Thienel

Length: 27 minutes

In this episode of The Life Science Report, Dr. Pete Bak and Back Bay Director, Christian Thienel catch up on the area attracting the most industry interest over the past couple of years: the anti-obesity space.

From big players looking to capitalize on the renewed interest in the obesity space to the staggering success of Novo Nordisk’s and Eli Lilly’s GLP-1 agonists (Ozempic, Wegovy, Mounjaro, and Zepbound) for glycemic control and weight loss, there’s a lot to cover.

Topics in this podcast include:

• A brief introduction to glucagon-like peptide 1 (GLP-1) agonists
• Why GLP-1s’ popularity is skyrocketing as treatment for type 2 diabetes and obesity
• How amylin and petrelintide (a long-acting amylin analogue) are being newly re-imagined for the obesity space, as well as muscle-targeted approaches like myostatin and activins
• Where BD and investor interest lies as these drugs are expected to have north of $150B in sales annually within the next decade
• What’s happening in early to late-stage drug development
• What the future holds for this sector, possibly to include cannabinoid one receptor inverse agonists and mitochondrial targets for metabolic disease

As always, thank you for joining us. Did you know we welcome listener questions? If there any areas you’d like us to explore further in metabolic disease and obesity, please let us know. Submit your questions here. Our Nordic-American Healthcare Conference 2025 will feature metabolic track. Learn more: https://nordicamericanhealthcareconference.com/

You can find previous episodes of the podcast here.