From NASH to MASH: Current Market Dynamics in Hepatology

After a summer away from podcasting, Back Bay Life Science Advisors’ Dr. Pete Bak and Christian Thienel are back on the mic to discuss current market dynamics in liver disease with a focus on one of the most closely watched space in hepatology, MASH. 

The big news includes a rebrand from NASH (non-alcohol related steatohepatitis) to MASH (metabolic dysfunction-associated steatohepatitis), the FDA approval of Madrigal Pharmaceutical’s Rezdiffra and real-time court rulings in Europe that may affect the rate of play for Ocaliva, a drug used to treat adults with primary biliary cholangitis here in the US. As Christian mentions in this episode, “The path to success is not always a straight line.”

Other topics in this podcast include: 

• Hepatology market dynamics over the past five years, including activity from Gilead, Novo Nordisk, Intercept and CymaBay 
• How treatment for primary biliary cholangitis, an autoimmune condition, went from a one to a three-product market 
• Payer monographs and what’s required for hepatology drugs
• The EMA recommendation earlier this month to revoke Ocaliva’s marketing authorization 
• Which companies are active in the rare liver disease space and how they differentiate themselves 

Thank you for listening. You can find previous episodes of the podcast here.

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