A Cross-Species Approach to Advancing Research in Phelan-McDermid Syndrome with Dr. Ben Scott and Amanda Fath

In this episode of the Phelan-McDermid Syndrome Podcast: Sharing Research, Progress, and Hope, we explore an innovative approach to translational neuroscience: cross-species research.

Dr. Lauren is joined by Dr. Benjamin Scott (Boston University) and Amanda Fath (MIT, Guoping Feng Lab) to discuss how researchers are using a shared, game-based task across humans, mice, and non-human primates to better understand how brain circuits influence perception, learning, and decision-making in Phelan-McDermid syndrome . Their short, engaging computer-based game (“Asteroids”) is more accessible to individuals with Phelan-McDermid syndrome. And the researchers remind us why "All data is good data".

This work aims to bridge a long-standing gap between animal models and human experience through computational models that connect behavior to underlying brain circuits. Ultimately, this work is aimed at improving how discoveries translate into meaningful treatments.

Research Participation Opportunity!The research team is currently recruiting individuals with Phelan-McDermid syndrome:

• Eligibility: 11–21 years old diagnosed with Phelan-McDermid syndrome; Able to use a touchscreen device or mouse; Do not have a seizure disorder or history of seizures that could be triggered by flashes
• Format: Fully virtual
• Time commitment: 20-40 minutes

If you’re unsure whether your loved one can participate—reach out. Even partial participation provides valuable data.

If interested in enrolling, or for more information, contact: geode.online.experiment@gmail.com or 203-216-9618